Contraindicated. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are affiliated with significant and/or everyday living-threatening activities.
ergotamine will improve the level or outcome of tazemetostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
ciprofloxacin will increase the level or result of caffeine by influencing hepatic enzyme CYP1A2 metabolism. Use Caution/Watch. The hepatic metabolism of caffeine can be lessened by ciprofloxacin; pharmacologic consequences of caffeine can be increased.
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Keep an eye on Intently (1)belzutifan will lessen the extent or outcome of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Check Closely (one)ergotamine will raise the amount or result of finerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
ergotamine will increase the stage or effect of tinidazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Where the mandatory results are created, a substance can be temporarily scheduled if It's not shown in any other program beneath 21 U.
Linezolid may increase serotonin on account of MAO-A inhibition. If linezolid needs to be administered, discontinue serotonergic drug quickly and monitor for CNS toxicity. Serotonergic therapy might be resumed 24 several hours just after very last linezolid dose or immediately after two months of checking, whichever comes initial.
Ergotamine is known to precipitate angina pectoris. For that reason the possibility of ergotism in sufferers getting nitroglycerin really should be considered.
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Coadministration of pexidartinib (a CYP3A4 inducer) with sensitive CYP3A substrates may well cause significant therapeutic failures. If concomitant use is unavoidable, raise the CYP3A substrate dosage in accordance with permitted product labeling.
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